Working Party on
Pharmaceutically Acceptable Salts of Drug Substances
Book tentative contents
PHARMACEUTICAL SALTS
Properties, Selection and Use
INTRODUCTION: Reasons
for salt formation
Objectives pursued in forming salts
PART 1: SALT FORMATION:
THE THEORETICAL BACKGROUND
- CHAPTER 1: Ionic equilibria
- CHAPTER 2: Evaluation of solid-state properties
of salts
- CHAPTER 3: Solubility and dissolution
- CHAPTER 4: Pharmaceutical aspects
PART 2: THE PRACTICE OF SALT FORMATION
- CHAPTER 5: Salt selection strategies
- CHAPTER 6: Biological effects of the drug salt
form
- CHAPTER 7: Industrial/large scale aspects of
salt preparation. Salt formation as a solution to industrial processing
- CHAPTER 8: Regulatory and Patent Issues
PART 3: LISTS , TABLES AND PROCEDURES
- CHAPTER 9: Individual salt-forming agent monographs:
a compilation of characteristics of various salt forming acids
- CHAPTER 10: Classification of the salt formers
- Table 1: Acids. Order: Increasing pKa
- Table 2: Bases. Order: Decreasing pKa
- Table 3: First class salt-formers
- Table 4: Second class salt-formers
- Table 5: Third class salt-formers (� exotic � salt-formers)
- CHAPTER 11 Examples of procedures
CONCLUSION
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