Number: 2004-025-1-700
Title: Compendium of targets of the top 100 commercially important
drugs
Task Group
Chairman: John
Proudfoot
Members: Erika Alapi, Janos
Fischer, Stefan Jaroch,
Susan Dana Jones,
Michael Liebman,
Tom Perun, Mark Samuels,
and Attila Szemzo
Completion Date: 2006 - project terminated
Objective:
To provide a compendium of the biological targets of the top 100
drugs.
Description:
A recent article (Fixing
the Drugs Pipeline, The Economist March 11 2004) indicated
that the 100 best selling target 43 gene products. However there does
not appear to be a resource where compiled target information is readily
available in a single source. The intention is to provide a resource
containing the following information on commercially important drug
targets: type of target (enzyme, receptor etc); brief description
of relevance to disease treated; reference to knockout information,
if available; reference to structural information, if available; listing
of the marketed drugs that interact with the target along with potency
and relevant selectivity information.