Pharmaceutical
Salts: Properties, Selection, and Use
A Handbook
Wermuth,
C.G. and Stahl, P.
H. (eds.)
Verlag Helvetica Chimica Acta, Z�rich, 2002
[ISBN 3-906390-26-8]
An
estimated half of all drug molecules used in medicine are administered
as salts, and the selection of a suitable salt for a drug candidate
is recognized as an essential step in the preclinical phase of drug
development. Surprisingly, however, the scientific literature on this
topic is rather limited and scattered throughout numerous journals and
patents. The majority of medicinal chemists in pharmaceutical industry
whose primary focus is the design and synthesis of novel compounds as
future drug entities are organic chemists for whom salt formation is
often a marginal activity restricted to the short-term objective of
obtaining crystalline material, and, because a comprehensive resource
that addresses the preparation, selection, and use of pharmaceutically
active salts has not been available, may forego the opportunities for
increased efficacy and improved drug delivery provided by selection
of an optimal salt. To fill this gap in the pharmaceutical bibliography,
we have gathered an international team of seventeen authors from academia
and pharmaceutical industry who, in their contributions to this volume,
present the necessary theoretical foundations as well as a wealth of
detailed practical experience in the choice of pharmaceutically active
salts.
Altogether, the contributions in this book reflect the multidisciplinary
nature of the science involved in selection of suitable salt forms for
new drug products. The editors have taken care to address every conceivable
aspect of the preparation of pharmaceutical salts. This book is destined
to be an essential reference for students of medicinal and pharmaceutical
chemistry, and an indispensable handbook for research-and-development
chemists, analytical chemists, biologists, development pharmacists,
regulatory and patent specialists, and medicinal scientists engaged
in preclinical development of drugs. This comprehensive up-to-date guide
will be an instructive companion for all scientists involved in research
and development of drugs and, in particular, of pharmaceutical dosage
forms.
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