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Medicinal Chemistry: Today and Tomorrow

M. Yamazaki

Blackwell Science,1996 [ISBN

Medicinal Chemistry: Today and Tomorrow presents the edited proceedings of the AFMC International Medicinal Chemistry Symposium. Medicinal chemistry is an interdisciplinary science covering a broad range of subjects but with chemistry as its core. The goal of medicinal chemistry is to produce effective new pharmaceuticals. The subject has seen remarkable advances in recent years, and Medicinal Chemistry: Today and Tomorrow provides a synthetic overview of the state of the art. This volume should make an important contribution to medicinal chemistry in its quest to produce innovative drugs that make the best use of recent developments in pharmaceutical research.


Preface; Antitumor taxoids; Prospects for pharmaceuticals from marine organisms; New lead structures in pharmacophore-based drug design; Targeting delivery of prostanoids and bioactive proteins; Cytokine receptors as a new tool for therapy of inflammation; Functional analysis of glutamate receptors by drug-based molecular approaches; Biologically active microbial metabolites; Total synthesis of natural products and designed molecules: brevetoxin B; Enzyme inhibitors for the treatment of AIDS; New approaches to the synthetic problems of myo-inositol phosphates and their biological utilities; Industrial bioconversions for chiral molecules, issues and developments; A new class of an orally active antidiabetic agent, insulin action enhancer: the development of Troglitazone; Kappa agonist phenothiazines: synthesis and SAR; A new class of diacidic nonpeptide angiotensin II receptor antagonists; Synthetic studies using sulfate radicals generated from peroxysulfates; Cataloytic
asymmetric carbon-carbon bond-forming reaction utilizing rare earth metal complexes; Design and development of practical asymmetric syntheses of drug candidates; Search for biologically active compounds from tropical plants; Marine pharmaceuticals: receptor/ligand interactions and cell signalling; Bioactive constituents of Chinese traditional medicine; An integrated approach to exploiting molecular diversity; Structures and functions of prostanoid receptors; Allylic nitro-oximes: an
original moiety pattern to store and release nitric oxide; Design and synthesis of novel potent, non-peptide and orally active renin inhibitors; Inhibition of HIV proteinase; Drug metabolism and toxicokinetics; Calcium-mediated mechanisms in chemically induced cell death; Targeted drug delivery to the brain using chemical delivery systems; Rational design of peptides with enhanced membrane permeability; Review on the development of a polymer conjugate drug: SMANCS; Moedulation of the carnohydrate structures of recombinant human glycoprotein therapeutics; Role of sphingoglycolipids in signal transduction, and their medicinal application for control of tumor progression
and inflammatory processes; Recent aspects of glycoconjugates synthesis: orthogonal glycosylation strategy; Chemical aspects of artificial gene regulatory molecules; Integrin adhesion receptors as targets for medicinal chemistry; Towards an orphan drug policy for the European Union; Support for orphan drug development: legislation in the United States, Japan and Europe; System for the orphan drug development in Japan; Design and pharmacological evaluation of a series of non-peptide endothelin ETA selective and ETA/ETB receptor antagonists; The DNA gyrase inhibitor cyclothialidine: progenitor of a new class of antibacterial agents; Novel AMPA/kainate receptor antagonists

153 illustrations
288 pages

© 1998 Blackwell Science Ltd

Page last modified 26 April 1999.
Copyright © 1997, 98, 99 International Union of Pure and Applied Chemistry.

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