27 No. 6
Analogue-Based Drug Discovery
J. Fischer and R.C. Ganellin (editors)
Wiley-VCH, 2006 [ISBN 3-527-31257-9]
Statistically, every second drug is an analogue, and their market value amounts to two-thirds of all drugs. Analogues are the most successful way of inventing a new drug and they provide the required improvements in drug therapy.
This is the first authoritative overview of past and current strategies for successful drug development by molecular modification of known leads. The book is a unique resource, which spans the important drug classes in most major therapeutic fields.
Analogue-based drug discovery is discussed among others, for beta blockers, ACE inhibitors, steroids, opiates, stigmines, proton pump inhibitors, platinum anti-cancer compounds, and anti-infective quinolones. Case studies, by the respective inventors of selected commercially successful drug analogues provide prime advice for new drug development projects based on analogue modification. The book includes a table of the most successful drug analogues as based on the IMS ranking and compares them in terms of chemical structure, mode of action, launch year, and patent priority.
last modified 28 December 2005.
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