Curiosity and simplicity in the invention and discovery of new metal-mediated
reactions for organic synthesis*
William B. Motherwell
Department of Chemistry, Christopher Ingold Laboratories,
University College London, 20 Gordon Street, London, WC1H OAJ, UK
Abstract: Two organometallic themes of current interest are
presented. The scope and generality of the reductive deoxygenation of
carbonyl compounds to organozinc carbenoids using zinc in combination
with a silicon electrophile is discussed. Alkoxycyclopropanation can
be achieved using orthoformates as substrates. Preliminary observations
on the development of a rhodium-catalyzed tandem hydrosilylationintramolecular
aldol sequence are discussed.
*Lecture presented at the 11th IUPAC International
Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
(OMCOS-11), Taipei, Taiwan, 22-26 July 2001. Other presentations are
presented in this issue, pp.1-186.
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