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Pure Appl. Chem. 75(11/12), 2429-2432, 2003

Pure and Applied Chemistry

Vol. 75, Issues 11-12

Use of gene expression profiling to understand the transcriptional program associated with estrogen-induced uterine growth

J. G. Moggs, D. G. Deavall, and G. Orphanides

Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK

Abstract: The use of gene expression data in predictive and mechanistic toxicology is hindered by a lack of information on the relationships between transcriptional events and physiological and pathological changes. We discuss the analysis of these relationships using the rodent uterotrophic response as a model experimental system for estrogen-induced uterine growth.

*Report from a SCOPE/IUPAC project: Implication of Endocrine Active Substances for Human and Wildlife (J. Miyamoto and J.Burger, editors). Other reports are published in this issue, pp. 1617-2615.


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