Synthesis of texaphyrin conjugates
D. J. Magda, Z. Wang, N. Gerasimchuk, W.-H. Wei, P. Anzenbacher Jr.,
and J. L. Sessler
Pharmacyclics Incorporated, 995 East Arques Avenue,
Department of Chemistry & Biochemistry, 1 University Station A5300,
The University of Texas at Austin, Austin, TX 78712-0165, USA
Abstract: This paper summarizes recent synthetic efforts devoted
to the generation of new, second-generation texaphyrin-type drugs, specifically
species that involve known or potential anticancer agents covalently
attached to a tumor-localizing texaphyrin core. Particular emphasis
will be placed on the strategies needed to prepare such systems, as
well as on the choice of active group being subject to attachment.
*Plenary lecture presented at the 2nd Santa Marķa Workshop
on Chemistry Devoted to Bioinorganic Chemistry, Santa Marķa del Mar,
Havana, Cuba, 7-11 July 2003. Other presentations are published in this
issue, pp. 321-388.
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