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Pure Appl. Chem. 76(2), 365-374, 2004

Pure and Applied Chemistry

Vol. 76, Issue 2

Synthesis of texaphyrin conjugates

D. J. Magda, Z. Wang, N. Gerasimchuk, W.-H. Wei, P. Anzenbacher Jr., and J. L. Sessler

Pharmacyclics Incorporated, 995 East Arques Avenue, Sunnyvale, CA
94085-4593 USA
Department of Chemistry & Biochemistry, 1 University Station A5300, The University of Texas at Austin, Austin, TX 78712-0165, USA

Abstract: This paper summarizes recent synthetic efforts devoted to the generation of new, second-generation texaphyrin-type drugs, specifically species that involve known or potential anticancer agents covalently attached to a tumor-localizing texaphyrin core. Particular emphasis will be placed on the strategies needed to prepare such systems, as well as on the choice of active group being subject to attachment.

*Plenary lecture presented at the 2nd Santa Marķa Workshop on Chemistry Devoted to Bioinorganic Chemistry, Santa Marķa del Mar, Havana, Cuba, 7-11 July 2003. Other presentations are published in this issue, pp. 321-388.

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