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Pure Appl. Chem. Vol. 76, No. 2, p. v-vi (2004)

Pure and Applied Chemistry

Vol. 76, Issue 2

Plenary lectures presented at the 2nd Santa María Workshop on Chemistry Devoted to Bioinorganic Chemistry
Santa María del Mar, Havana,Cuba, 7-11 July 2003

> link to conference calendar

The 2nd Santa María Workshop took place on 7-10 July 2003 in Santa María del Mar, Havana, Cuba and was devoted to bioinorganic chemistry. The workshop focused on five main areas:metal interaction with DNA and nucleotides, metalloporphyrins, copper compounds, metal nitrosyls, and the influence of genomics on bioinorganic chemistry. The workshop was organized by the University of Havana and the Cuban Chemical Society. Professor Roberto Cao, chairman of the workshop, and his bioinorganic chemistry lab were responsible for most of the organizing activity.

In his opening lecture, Prof. Stephen Lippard (MIT) presented an excellent overview on cisplatin, a research area in which he is a world specialist. His lecture, entitled “Case history and recent advances in understanding cisplatin”, gave the results of his research, mainly the removal of cisplatin adducts from DNA by nucleotide excision repair (NER) and the specific binding of high-mobility group (HMG) domain proteins to the major cisplatin-DNA adducts. Prof. Helmut Sigel (Univ. Basel) provided another look at metal-DNA interaction in his plenary lecture, entitled “Adenosine 5'-triphosphate (ATP4-): Aspects of the coordination chemistry of a multitalented biological substrate”. Prof. Sigel focused on self-association of ATP4- and how metal coordination influences this process.

Prof. Ivano Bertini (Univ. Florence) introduced genomics in his plenary lecture entitled “Perspectives in inorganic structural biology”. He described how genomics is influencing further development in bioinorganic chemistry, a very novel topic. He presented the latest results obtained at the Magnetic Resonance Center of the University of Florence, which he leads, on the proteins involved in the homeostasis of copper. Copper(I) chaperone proteins, such as Atx1, Ccc2, and CopZ, received special attention.

Studies on metalloporphyrins were introduced by Prof. Jonathan L. Sessler (Univ.Texas at Austin). He presented the main results achieved at the University of Texas and Pharmacyclics Inc. on lanthanide(III) texaphyrins (Tex), a family of expanded porphyrins containing five nitrogen donor atoms. He presented interesting results on the biological studies, including phase III clinical trials, of Gd-Tex (registered as Xcytrin). This compound acts as a radiation sensitizer in the treatment of brain metastases. It is assumed that this compound works selectively on the mitochondria of neoplasic cells through the development of an acute oxidative stress.

Prof. Peter Ford (Univ. California at Santa Barbara) presented a plenary lecture entitled “Probing fundamental mechanisms of nitric oxide reactions with metal centers and other biologically relevant targets”. He presented the results of kinetic studies on several aspects of metal-nitrosyl interactions, namely, formation of ferri-and ferro-heme nitrosyl complexes, reductive nitrosylation of Fe(III) porphyrins, and reactions that potentially involve the ubiquitous NxOy impurities resulting from NO auto-oxidation in aqueous and hydrophobic media.

Prof. Wolfgang Kaim (Univ. Stuttgart) presented an interesting plenary lecture entitled “Cooperation of metals with electroactive ligands of biochemical relevance:Beyond metalloporphyrins”. He focused on the redox processes that take place in Mo (or W) oxotransferases and copper-topaquinone. In the latter case, an intramolecular electron transfer takes place.

The next workshop in the series, III SMWC, will take place on 12-15 July 2004 and will be devoted to supramolecular chemistry.

Roberto Cao
Conference Editor

Organizing Committee: R.Cao (Chairman), A. Fragoso (Secretary), A. Diaz, R. Gonzalez, M. Ortiz, I. Sanchez.


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