Total synthesis and structural elucidation of natural products: (–)-Delactonmycin, (+)‑plumerinine, and (–)-parvistemoamide*
Ronaldo A. Pilli, Ivan R. Corrêa Jr., Adriano O. Maldaner, and Giovanni B. Rosso
Instituto de Química, Unicamp P.O. Box 6154, 13084-971, Campinas, SP Brazil
Abstract: Synthetic studies that established the relative configuration of (–)-delactonmycin, a polyketide with inhibitory activity against HIV-1 Rev protein, and our efforts toward the structural elucidation of the alkaloids (+)-plumerinine, isolated from P. rubra, and (–)-parvistemoamide, isolated from S. parviflora, are discussed.
Keywords: natural products; structural elucidation; delactonmycin; plumerinine; parvistemoamide.
*An issue of reviews and research papers based on lectures presented at the 15th International Conference on Organic Synthesis (ICOS-15), held in Nagoya, Japan, 1-6 August 2004, on the theme of organic synthesis. Other presentations are published in this issue, pp. 1087-1296.