Development of homogeneous and heterogeneous asymmetric catalysts for practical enantioselective reactions*
Kuiling Ding
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China
Abstract: Two strategies for the development of practical asymmetric catalysis have been discussed in this article. The first part of this article focuses on the design and screening of highly efficient and enantioselective chiral catalysts for asymmetric hydrogenation reactions employing combinatorial approach. The second part presents a conceptually new strategy (i.e., "self-supporting" approach) for the immobilization of homogeneous catalysts through assembly of chiral multitopic ligands and metal ions without using any support. The success of this strategy will be exemplified in heterogeneous asymmetric carbonyl-ene, sulfoxidation, and epoxidation, as well as in asymmetric hydrogenation reactions.
Keywords: chiral; asymmetric catalysis; homogeneous; heterogeneous; hydrogenation; oxidation; C-C bond formation.
*Pure Appl. Chem. 78, 197-523. An issue of reviews and research papers based on lectures presented at the 13th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS-13), Geneva, Switzerland, 17-21 July 2005.