WORKING GROUP ON ORGANIC TRACE ANALYSIS
Number: 521/12/95
Title: Direct derivatization of organic compounds at trace level
concentrations for fluorescence detection and capillary electrophoresis
Series: Analytical Techniques for Trace Organic Compounds
Coordinator(s): L.-G.
Danielsson
Remarks: Commission V.3
Completion Date: 1999 - project abandoned
Objective:
Derivatization of trace organic compounds to enhance the separation
of trace compounds from the matrix or from other interfering components
has been developed for several chromatographic techniques. Further,
well chosen derivatives can enhance the detection capabilities of a
given system considerably. Even though HPLC is generally considered
a technique which needs no derivatization, under special circumstances
such a step can be great advantage, particularly to put detectors with
superior detection capabilities to use or to allow a change of phases
such as from straight phase to reversed phase. For trace analysis of
real world samples in difficult matrices this is a relevant option and
needs consideration. In this project the possibilities, advantages and
disadvantages shall be discussed in such a critical manner that the
reader can consider to use this option avoiding the already known pitfalls.
Progress:
project abandoned
Last update: 16 August 1999
