Number: 2006-023-3-100
Title: Recommendations for nomenclature and
databases for biochemical thermodynamics
Task Group
Chairman: Robert
Alberty
Members: Athel
Cornish-Bowden, Hal
Dixon, Robert N.
Goldberg, Gordon Hammes,
Keith Tipton, and
Hans V. Westerhoff
Objective:
To revise IUPAC Recommendations for Nomenclature and Tables in Biochemical
Thermodynamics 1994*. Update these recommendations and increase their
usefulness by providing more about computers and databases that have
been developed since 1994. Describe the connection between the thermodynamics
of enzyme-catalyzed reactions and the kinetics of enzyme-catalyzed
reactions that is provided by Haldane relations.
*Pure Appl. Chem. 66, 1641-1666 (1994) >
link to issue
content to access ful text
Description:
The concept of a transformed Gibbs energy G' that provides the
criterion for spontaneous change and equilibrium at a specified pH
was developed in 1992 (Alberty, Biophys. 42, 117-131 and 43,
239-254), and so it is quite remarkable that the IUPAC Recommendations
were published in Pure Appl. Chem. 66, 1641-1666 (1994). They
were reprinted in Eur. J. Biochem. 240, 1-14 (1996).
A lot has happened in the field since 1994, especially
the use of computers and the publication of articles and putting databases
on the web. A book titled 'Biochemical
Thermodynamics: Applications of Mathematica (Wiley, Hoboken, NJ
(2006), ISBN: 0-471-75798-5) that gives apparent equilibrium constants
at 298.15 K, 0.25 M ionic strength, and pHs 5 to 9 for over 300 enzyme-catalyzed
reactions was written by the Task Group Chair.
These Recommendations are to be published as IUPAC-IUBMB
Joint Commission on Biochemical Nomenclature (JCBN).
The Sections to be drafted include: