Fluorous methods for synthesis and separation of organic molecules*
Dennis P. Curran
Department of Chemistry, University of Pittsburgh,
Pittsburgh, PA 15260 USA
Abstract: Fluorous molecules partition out of an organic phase
and into a fluorous (highly fluorinated) phase in a liquid-liquid extraction.
New fluorous techniques allow simple yet substantive separations of
organic reaction mixtures based on the presence or absence of a fluorous
tag. Fluorous-tagged molecules can also be separated from nontagged
molecules by solid phase extraction over fluorous reverse-phase silica
gel. This technique is ideal for solution-phase parallel synthesis because
it allows simple yet substantive separations of organic reaction mixtures.
*Lecture presented at the 13th International
Conference on Organic Synthesis (ICOS-13), Warsaw, Poland, 1-5 July
2000.
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