Synthetic studies on the A83586C and bryostatin antitumor macrolides
and the monamycin antibiotics*
K. J. Hale**, M. G. Hummersone, J. Cai, S. Manaviazar, G.
S. Bhatia, J. A. Lennon, M. Frigerio, V. M. Delisser, A. Chumnongsaksarp,
N. Jogiya, and A. Lemaitre
The Christopher Ingold Laboratories, Department of
Chemistry, University College London, 20 Gordon Street, London WC1H
0AJ, UK
Abstract: After a brief summary of our asymmetric total syntheses
of A83586C and 4-epi-A83586C, we will go on to describe some
of our synthetic work on the monamycins, and our most recent total synthesis
studies on the bryostatin antitumor macrolides.
*Lecture presented at the 13th International
Conference on Organic Synthesis (ICOS-13), Warsaw, Poland, 1-5 July
2000.
** Corresponding author
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