Recent advances in asymmetric catalysis. Synthetic applications
to biologically active compounds*
Jean Pierre Genet**, Angela Marinetti, and Virginie Ratovelomanana-Vidal
E. N. S. C. P. , Laboratoire de Synthèse Sélective
Organique et Produits Naturels, C. N. R. S. (UMR 7573) , 11 rue Pierre et
Marie Curie, 75231 Paris Cedex 05, France
Abstract: New chiral cationic ruthenium complexes have been
used for the industrial synthesis of (+) -dihydrojasmonate. A new class
of electron-rich C2-symmetric 2,4-disubstituted phosphetanes
(CnrPHOS) was developed. Preliminary evaluation of their catalytic properties
revealed high efficiency in rhodium and ruthenium-catalyzed asymmetric
hydrogenations. A new stereochemical model is presented in which the
phosphetane Rh-catalyzed hydrogenation follows an apparent stability-controlled
mechanism.
* Lecture presented at the XIXth International Conference
on Organometallic Chemistry (XIX ICOMC) , Shanghai, China, 23-28 July
2000. Other presentations are published in this issue, pp. 205-376.
** Corresponding author
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