Chemical and biological safety: Biosensors and nanotechnological
methods for the detection and monitoring of chemical and biological
agents
S. Varfolomeyev1,*, I. Kurockhin1,2, A. Eremenko1,2,
and E. Efremenko1
1 The Lomonosov Moscow State University, Faculty
of Chemistry, Chemical
Enzymology Department, Lenin s Hills, 1/11, Moscow, 119992 Russia;
2 Russian Center of Molecular Diagnostics and Therapy, Simferopolsky
b-r, 8, Moscow 1131439, Russia
Abstract:
The elaboration of highly sensitive and express methods for quantitative
and qualitative detection and monitoring of chemical warfare agents
(CWA), organophosphate and carbamate pesticides, compounds with delayed
neurotoxicity, and pathogenic microorganisms and viruses is discussed.
The application of potentiometric and amperometric biosensors, automatic
biosensors discriminating the neurotoxins of different classes, is performed.
The information about biosensors detecting the compounds with delayed
neurotoxicity through the evaluation of neurotoxic esteraseactivity
in the blood is presented. The use of immunochip technology for the
detection of pathogenic microorganisms and viruses is demonstrated.
The enzymatic methods of destruction of organophosphorus neurotoxins
are considered as the base of new defense technology.
*Lecture presented at the IUPAC Workshop, Impact of
Scientific Developments on the Chemical Weapons Convention, Bergen,
Norway, 30 June-3 July 2002. Other presentations are published in this
issue, pp. 2229-2322.
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