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IUPAC/SCOPE Project
Environmental implications
of endocrine active substances: Present state-of-the-art and future
research needs
> Access
to Project Description
Topic 1
- Molecular
Mode of Action of Nuclear Receptors; Fundamentals for Understanding
the Action of Endocrine Active Substances
Coordinators: Dr. W. Kelce and Dr. Kenneth Korach (NIEHS, Research
Triangle Park, NC, USA)
-
Nuclear receptor superfamily (nuclear receptor
superfamily members, structure similarity/diversity, function
DNA gene response elements and sequence recognitions)
Prof. P. Chambon (France)
-
Mode of action of coactivators and corepressors
Dr. B. O'Malley (USA)
-
Function and mode of action of nuclear receptors;
estrogen, progesterone and vitamin D
Dr. D. McDonnell (USA)
-
Biological function and mode of action of the
androgen receptor
Dr. E. Wilson (USA)
-
Biological function and mode of action of nuclear
receptors; glucocorticoid and mineralcorticoid
Dr. G. Schutz (France)
-
Biological function and mode of action of retinoid
nuclear receptors
Dr. H. Gronemeyer (France)
-
Biological function and mode of action of orphan
nuclear and thyroid hormone receptors
Dr. R. Evans (USA)
-
Molecular mechanisms of cross-talk between growth
factors and nuclear receptor signaling
Dr. D. Picard (Switzerland)
-
Nuclear hormone receptor action through classical
and alternative target genes
Dr. P. Kushner (USA)
-
Nuclear receptor action involved with gonadal
differentiation
Dr. I. Hughes (USA)
-
Hereditary diseases related to nuclear receptor
gene mutation
Dr. L. Jamenson (USA)
-
Interaction of exogenous endocrine active substances
with nuclear receptors
Dr. J. Katzenellenbogen (USA)
Topic
2 - Environmental Fate and Metabolism of Endocrine Active
Substances
Coordinator: Prof. W. Klein
-
Introduction
Prof. W. Klein
-
Technologies for the Detection of Endocrine Active
Substances in Food and the Environment
Dr. P. Holland (New Zealand)
-
Releases into the Environment of Natural Hormones
from Humans, Wildlife and Livestock, their Excretion and their
Initial Concentrations in Soil, Water, Food and Feed
Dr. L. Shore (Israel)
-
Concentration of Phytohormones in Food and Feed,
their Release into the Environment, and their Initial Concentrations
in Soil and Water
Dr. P. Verger (France)
-
Release into the Environment of Synthetic Hormones
and Other Endocrine Active Pharmaceuticals from Humans and Livestock,
their Excretion and their Initial Concentrations in Soil, Water,
Food and Feed
Dr. F. Ingerslev (Denmark)
-
Releases of Industrial Chemicals by Different
Pathways into the Environment and their Initial Concentrations
in Soil and Water Contributor
to be identified
-
Releases of Pesticides by Agricultural Pathways
into the Environment and their Initial Concentrations in Soil
and Water
Dr. K. Racke (USA)
-
Degradation, Persistence and Accumulation of Endocrine
Active Substances in Water and Soil
Dr. A. Katayama (Japan)
-
Metabolism of Endocrine Active Substances in Mammals
Dr. N. Kurihara (Japan)
-
Metabolism of Endocrine Active Substances in Aquatic
and Terrestrial Organisms
Dr. M. van den Berg (Netherland)
-
Environmental Concentrations of Endocrine Active
Substances
Dr. T. Ternes (Germany)
-
Environmental Exposure Modeling of Endocrine Active
Substances
Dr. P. de Voogt (Netherland)
-
Prioritization of Information Needs to Improve
Exposure Analysis and Global Conclusion
Joint authorship
Topic
3 - Effects of Endocrine Active Chemicals in Rodents and
Humans, and Risk Assessments for Humans
Coordinators: Prof. J. Ashby and Dr. J. Lamb
Humans
-
Trends in Human Male Reproductive Health: Hypospadia,
Testicular Cancer and Sperm Count
Dr. N. Skkakebaek. (Denmark)
-
Breast Cancer Incidence and Mortality and its
Potential Relationship with Exposure to Environmental Hormones
Dr. J. Li (USA)
-
Predictions and Observations in Human Populations:
Trends in Hormone-mediated Diseases in Developing Children
Dr. M. New (USA)
-
Human Health Effects of Endocrine Disrupting Chemicals:
Weight of the Evidence
Dr. J. Vos (Germany)
-
Balancing of Beneficial and Adverse Effects of
Hormonally Active Agents
Dr. K. Setchell (USA)
-
Hormonally Active Agents and Plausible Relationships
to Adverse Effects on Human Health
Dr. T. Inoue (Japan)
Animals
-
Biosynthesis, Metabolism and Transport of Steroid
and Thyroid Hormones and Feedback Mechanisms: Rodent/Human Differences
Dr. K. Pak (UK) or J. Katzenellenbogen (USA)
-
Comparative Physiology of Reproductive Endocrine
Systems and Hypophyseal Gonadal Functions in Rodents as Surrogates
for Humans
Dr. S. Tyl (USA)
-
Significance of Experimental Studies for Assessing
Adverse Effects of Endocrine, Active Substances in Humans
Dr. E. Gray (USA)
-
Evaluation of Observed Adverse Effects of Endocrine
Active Substances on Reproduction and Development, Nervous and
Immune Systems
Dr. R. Chapin (USA)
Risk Assessment
-
Modification of Endocrine Active Potential by
Mixtures (Synergism, Additivity and Antagonism)
Dr. K. Gaido (USA)
-
Determination of the TDI (Tolerable Daily Intake
for Humans) and PNEC (Predicted No Effect Concentration in Environmental
Species): Animal Models to Ensure Human Safety
Dr. P. Fenner-Crisp (USA)
-
Dose Response Assessment, Including Low Dose Extrapolations
and Consideration of Hormesis
Dr. H. Baron (USA)
-
Use of NOAEL, Benchmark Dose, and Other Models
for Human Risk Assessment of Hormonally Active Substances
Dr. C. Kimmel (USA)
-
Current Views on the Risk Assessment of Hormonally
Active Substances
Dr. S. Barlow (USA)
-
Weighing the Evidence: Assessing Data Quality
or Reliability for Responses to Hormonally Active Substance
Dr. M. Shelby (USA)
Topic
4 - Effects of Endocrine Active Substances on Wildlife Species
Coordinator: Prof. J. Sumpter
-
An Historical Perspective
Prof. J. Sumpter (UK)
-
Endocrine Disruption in Invertebrates: The TBT
Story
Dr. J. Oehlman (Germany)
-
Endocrine Disruption in Freshwater Fish
Dr. S. Jobling (UK)
-
Endocrine Disruption in Marine Fish
Dr. P. Matthiessen (UK)
-
Deformed Frogs and Environmental Retinoids
Dr. B. Blumberg (USA)
-
Effects of Endocrine Disrupting Chemicals on Sex
Determination and Differentiation in Reptiles
Dr. L. Guillette (USA)
-
Central Effects of Endocrine Disrupting Chemicals
in Birds
Dr. M. Fry (USA)
-
Animal Models for the Study of Low Doses and Mixtures
of Endocrine Disrupting Chemicals
Dr. D. Crews (USA)
-
Full Life Cycle Tests for Endocrine Disrupters
Using Fish
Dr. H. Yokota (Japan)
-
Fate and Behavior of Endocrine Active Chemicals
in the Environment
Dr. A. Johnson (UK)
-
Environmental Risk Assessment for Endocrine Active
Substances Present in the Environment
Dr. T. Bowmer (Netherland)
-
A Governmental View of Endocrine Disrupters in
Wildlife
Dr. K. Cameron (UK)
-
Endocrine Disruption in Wildlife: The Future
Prof. J. Sumpter (UK)
Page last modified 22 May 2001
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